Education and recognition

Degrees

Fellowships

Competitive training awards held during postdoctoral research.

Publications

Thirteen peer-reviewed papers: two as first author and one as co-first author. My industry work at Intellia Therapeutics and Emmune was kept out of the public domain by company policy, so this record reflects my academic and postdoctoral research.

• ORCID 0000-0001-6094-6410
• Google Scholar

• The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia. Reed R, Park K, Waddell B, Timbers TA, Li C, Baxi K, Giacomin RM, Leroux MR, Carvalho CE. Sci Rep. 2023 Jun 9;13(1):9410. doi:10.1038/s41598-023-36430-8
• Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma. Co-first author Chen J, Baxi K, Lipsitt AE, Hensch NR, Wang L, Sreenivas P, Modi P, Zhao XR, Baudin A, Robledo DG, Bandyopadhyay A, Sugalski A, Challa AK, Kurmashev D, Gilbert AR, Tomlinson GE, Houghton P, Chen Y, Hayes MN, Chen EY, Libich DS, Ignatius MS. eLife. 2023 Jun 2;12:e68221. doi:10.7554/eLife.68221
• The RNA demethylase ALKBH5 maintains endoplasmic reticulum homeostasis by regulating UPR, autophagy, and mitochondrial function. Subbarayalu P, Yadav P, Timilsina S, Medina D, Baxi K, Hromas R, Vadlamudi RK, Chen Y, Sung P, Rao MK. Cells. 2023 Apr 29;12(9):1283. doi:10.3390/cells12091283
• Vertical inhibition of the RAF-MEK-ERK cascade induces myogenic differentiation, apoptosis, and tumor regression in H/NRAS^Q61X mutant rhabdomyosarcoma. Garcia N, Del Pozo V, Yohe ME, Goodwin CM, Shackleford TJ, Wang L, Baxi K, Chen Y, Rogojina AT, Zimmerman SM, Peer CJ, Figg WD, Ignatius MS, Wood KC, Houghton PJ, Vaseva AV. Mol Cancer Ther. 2022 Jan;21(1):170-183. doi:10.1158/1535-7163.MCT-21-0194
• SNAI2-mediated repression of BIM protects rhabdomyosarcoma from ionizing radiation. Wang L, Hensch NR, Bondra K, Sreenivas P, Zhao XR, Chen J, Moreno Campos R, Baxi K, Vaseva AV, Sunkel BD, Gryder BE, Pomella S, Stanton BZ, Zheng S, Chen EY, Rota R, Khan J, Houghton PJ, Ignatius MS. Cancer Res. 2021 Nov 1;81(21):5451-5463. doi:10.1158/0008-5472.CAN-20-4191
• Zebrafish tumor graft transplantation to grow tumors in vivo that engraft poorly as single cell suspensions. Lipsitt A, Hensch NR, Moreno-Campos R, Baxi K, Chen J, Challa AK, Chen EY, Ignatius MS. Zebrafish. 2021 Aug;18(4):293-296. doi:10.1089/zeb.2021.0006
• Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in fusion negative rhabdomyosarcoma. Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Nat Commun. 2021 Jan 8;12(1):192. doi:10.1038/s41467-020-20386-8
• Akirin is required for muscle function and acts through the TGF-β Sma/Mab signaling pathway in Caenorhabditis elegans development. Bowman R, Balukoff N, Clemons A, Koury E, Ford T, Baxi K, Egydio de Carvalho C, Smolikove S. G3 (Bethesda). 2020 Jan 7;10(1):387-400. doi:10.1534/g3.119.400377
• tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish. Ignatius MS, Hayes MN, Moore FE, Tang Q, Garcia SP, Blackburn PR, Baxi K, Wang L, Jin A, Ramakrishnan A, Reeder S, Chen Y, Nielsen GP, Chen EY, Hasserjian RP, Tirode F, Ekker SC, Langenau DM. eLife. 2018 Sep 7;7:e37202. doi:10.7554/eLife.37202
• Assessing lysosomal alkalinization in the intestine of live Caenorhabditis elegans. First author Baxi K, de Carvalho CE. J Vis Exp. 2018 Apr 13;(134):57414. doi:10.3791/57414
• Rapid nuclear exclusion of Hcm1 in aging Saccharomyces cerevisiae leads to vacuolar alkalization and replicative senescence. Ghavidel A, Baxi K, Prusinkiewicz M, Swan C, Belak ZR, Eskiw CH, Carvalho CE, Harkness TA. G3 (Bethesda). 2018 May 4;8(5):1579-1592. doi:10.1534/g3.118.200161
• Regulation of lysosomal function by the DAF-16 forkhead transcription factor couples reproduction to aging in Caenorhabditis elegans. First author Baxi K, Ghavidel A, Waddell B, Harkness TA, de Carvalho CE. Genetics. 2017 Sep;207(1):83-101. doi:10.1534/genetics.117.204222
• A genome scale screen for mutants with delayed exit from mitosis: Ire1-independent induction of autophagy integrates ER homeostasis into mitotic lifespan. Ghavidel A, Baxi K, Ignatchenko V, Prusinkiewicz M, Arnason TG, Kislinger T, Carvalho CE, Harkness TA. PLoS Genet. 2015 Aug 6;11(8):e1005429. doi:10.1371/journal.pgen.1005429

International presentations

• 2019 Syngeneic tp53 null mutants develop multiple transplantable tumors and reveal a role for tp53 in metastasis in embryonal rhabdomyosarcoma. Childhood Cancer Symposium · Poster
• 2018 tp53 deficiency causes a wide tumor spectrum and elevates embryonal rhabdomyosarcoma metastasis in zebrafish. 13th International Zebrafish Conference, University of Wisconsin, Madison · Poster
• 2014 Coupling lysosomal function to lifespan and reproduction in C. elegans. Aging, Metabolism, Pathogenesis, Stress, and Small RNAs in C. elegans, University of Wisconsin, Madison · Invited speaker
• 2014 Role of the lipid transcription factor SBP-1 and its downstream genes in dopaminergic neuron degeneration in C. elegans. 8th Annual Canadian Neuroscience Meeting · Poster
• 2013 The role of the C. elegans Shugoshin homolog in sensory neurons. C. elegans International Meeting, University of California, Los Angeles · Poster
• 2013 RER-1: finding new roles for an old protein. C. elegans International Meeting, University of California, Los Angeles · Poster

Institutional and regional presentations

• 2018 tp53 deficiency elevates metastasis without affecting cancer stem cells in a zebrafish model of embryonal rhabdomyosarcoma. Department of Molecular Medicine, UT Health San Antonio · Oral presentation, third place
• 2018 tp53 deficiency causes a wide tumor spectrum and elevates embryonal rhabdomyosarcoma metastasis in zebrafish. Annual Research Symposium, Mays Cancer Center, UT Health San Antonio · Poster, first place
• 2014 The role of the autophagy lysosome pathway in aging and reproduction. Department of Biology, University of Saskatchewan · Oral presentation
• 2013 RER-1: finding new roles for an old protein. Department of Biology, University of Saskatchewan · Oral presentation
• 2010 Elucidating the role of the Rep DNA helicase in replication restart in E. coli. Boston Bacterial Meeting, Harvard University · Poster
• 2007 Investigating the genetic requirements for recombination coupled replication restart in E. coli. Department of Microbiology, University of Saskatchewan · Poster

Mentoring and supervision